| Symbol
| ANGPTL4
| contributors: mct/pgu - updated : 21-01-2018
|
| HGNC name
| angiopoietin-like 4
|
| HGNC id
| 16039
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
|
| |
aberrant methylation of this gene is associated with human gastric cancers | | tumoral
|
|
| --over
|
| |
increased expression of the protein is associated with breast cancer metastasis to the lungs | | constitutional
|
|
| --low
|
| |
decreased expression of this protein is associated with type 2 diabetes | | constitutional
|
|
| --low
|
|
protects against the development and progression of atherosclerosis  | | constitutional
|
|
| --over
|
| |
higher in patients with the metabolic syndrome than in subjects without the metabolic syndrome | | constitutional
|
|
| --low
|
| |
in macrophages by TLR activators could lead to a variety of down-stream effects important in host defense and wound repair | |
| Susceptibility
|
to lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol |
| Variant & Polymorphism
other
| variant E40K increase suceptibility to the lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol |
|
variant E40K destabilizes the protein after secretion, preventing the extracellular accumulation of oligomers and abolishing the ability of the protein to inhibit LPL activity |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| diabete | | | |
| prime therapeutic candidate for the treatment of diabetic wounds | | cancer | metastases | | |
| good therapeutic inhibitor of metastases | | cardiovascular | atheroma | | |
| targeted silencing offers a potential therapeutic strategy for the treatment of dyslipidemia and atherosclerosis | | metabolism | lipid | triglyceride | |
| therapeutic antibodies that neutralize ANGPTL4 and ANGPTL3 may be useful for treatment of some forms of hyperlipidemia | | neurosensorial | visual | | |
| could be an important target for the treatment of macular edema |
| | | |
|
| Angptl4-deficient mice exhibit delayed wound reepithelialization with impaired keratinocyte migration |