Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C21orf91 contributors: mct - updated : 03-05-2021
HGNC name chromosome 21 open reading frame 91
HGNC id 16459
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY EURL family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • is an important new player in neuronal development that is likely to impact on the neuropathogenesis of HSA21-related disorders including Down Syndrome
  • important for accurate oligodendroglial differentiation, influencing their capacity to mature and to myelinate axons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C21orf91 interacts with the coiled-coil domain-containing protein CCDC85B so as to modulate CTNNB1 levels in cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    elevated C21orf91 expression levels induce a gliogenic shift towards the astrocytic lineage reflecting non-equilibrated glial cell populations in Down syndrome brains
    Susceptibility to cold sore
    Variant & Polymorphism
  • different alleles of the newly described gene C21orf91 affect the expression of cold sore phenotypes
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS