| Symbol
| TRIM29
| contributors: mct - updated : 18-01-2023
|
| HGNC name
| tripartite motif-containing 29
|
| HGNC id
| 17274
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
in many human cancers ( | | tumoral
|
|
| --over
|
| |
in most invasive pancreatic cancers and pancreatic cancer precursor lesions | | tumoral
|
|
| --low
|
| |
in prostate and breast cancer | | tumoral
|
|
| --over
|
| |
high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression in gastrointestinal tumor | | tumoral
|
|
|
|
| |
in Cutaneous Squamous Cell Carcinoma | | tumoral
|
|
| --over
|
| |
in gastric cancer tissues compared with their corresponding normal tissues | | tumoral
|
|
|
| gain of function
| |
in cervical cancer tissues when compared with the matched adjacent cervical tissues | | tumoral
|
|
|
| loss of function
| |
could inhibit the growth and proliferation partly through regulation of CCNE in esophageal squamous cell carcinoma (ESCC) | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| may be a potential prognostic biomarker for cervical cancer | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | reproductive | uterus | |
| therapeutic target for cervical cancer |
| | |
|
| TRIM29 -/- mice have lower adenovirus titers in the lung, and are resistant to lethal herpes simplex virus-1 infection due to enhanced production of type I interferon |