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FLASH GENE

Symbol

AP2A2

contributors: npt/ - updated : 30-03-2006

HGNC name	adaptor-related protein complex 2, alpha 2 subunit
HGNC id	562

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	86.40 kb     22 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed AP2A2 22 - 4616 104 939 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Nervous brain       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Ap2a2 adaptor protein complex AP-2 alpha 2 subunit

Homologene

FAMILY

adaptor complexes large subunit family

CATEGORY

adaptor , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	endocytic coated vesicles

basic FUNCTION

AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

component of AP-2 adaptor complex, clathrin coat assembly complex

INTERACTION

DNA

RNA

small molecule

protein

HIP1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS