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FLASH GENE
Symbol PCDH20 contributors: mct - updated : 15-04-2020
HGNC name protocadherin 20
HGNC id 14257
Location 13q21.2      Physical location : 61.983.820 - 61.989.655
Synonym name protocadherin 13
Synonym symbol(s) PCDH13, FLJ22218
DNA
TYPE functioning gene
STRUCTURE 5.84 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4786 - 951 - 2015 24910204
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vessel    
Hearing/Equilibriumearinnercochlea   Mus musculus
Nervousbrainforebraincerebral cortexoccipital cortex  Homo sapiens
 brainforebraincerebral cortexparietal cortex  Homo sapiens
 nervecranial nerve    Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumhair cell receptor Mus musculus
Olfactoryolfactory receptor Mus musculusFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • six extracellular cadherin domains
  • a transmembrane domain encoded by a large unique exon and a cytoplasmic tail
  • a protein phosphatase-1alpha (PP1alpha) binding domain (RRVTF, CM3)
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,nuclear envelope,int
    text
  • integral plasma membrane, putatively localized at the synaptic junction
  • highly expressed in a subset of taste bud cells, the sweet- or umami-sensitive taste cells
  • basic FUNCTION
  • cadherin related neuronal receptor, putatively involved in the specificty of the neuronal connections
  • may play specific roles in the establishment of selective synaptic connections of specific modality of cerebral cortex with other communicating brain regions such as the thalamus
  • play likely roles in the wiring of neural circuit formation and maintenance through its adhesive and regulatory mechanism
  • PCDH8, PCDH9, PCDH17 and PCDH20 genes are located around 13q21.1 and might be broadly involved in tumor suppression in a variety of tumors
  • is a functional tumor suppressor and an important antagonist of WNT/CTNNB1 signaling and epithelial-mesenchymal transition (EMT), with frequent epigenetic inactivation in Nasopharyngeal Carcinoma
  • likely specific role in the sensory epithelium of the utricle and cochlea
  • involved in the disruption of hypopharyngeal squamous cell carcinoma (HSCC) progression through antagonizing its downstream WNT/CTNNB1 signalling pathway
  • may be involved in taste quality-specific connections between differentiated taste cells and their partner neurons, thereby acting as a molecular tag for the coding of sweet and/or umami taste
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other cell cellhomophilic interaction
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    epigenetic silencing by hypermethylation of the CpG-rich promoter in non-small-cell lung cancer (NSCLC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • downregulated PCDH20 may serve as reliable diagnostic biomarker in hypopharyngeal squamous cell carcinoma (HSCC)
  • may represent a novel prognostic biomarker for hepatocellular carcinoma (HCC) patients
  • Therapy target
    ANIMAL & CELL MODELS