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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PCDH17

contributors: mct - updated : 21-04-2020

HGNC name	protocadherin 17
HGNC id	14267

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   silenced by DNA methylation in acute myeloid leukemia (AML) tumoral     --low   by aberrant methylation of PCDH17 gene in high-grade serous ovarian carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PCDH17 methylation may be a tumor-specific event and can be used as an epigenetic biomarker for nasopharyngeal carcinoma (NPC)
	PCDH17 methylation in serum is a frequent event in Renal Cell Carcinoma and associated with risk factors of poor outcomes
	PCDH17 methylation at diagnosis was closely related to poor prognosis and thus could be used as a new biomarker to predict relapse in patients with B-cell precursor (BCP) acute lymphoblastic leukemia (ALL)
	detection of PCDH17 promoter methylation in serum-derived DNA may be a convenient and noninvasive predictive biomarker in routine clinical practice
Therapy target

ANIMAL & CELL MODELS