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FLASH GENE
Symbol DCHS1 contributors: mct - updated : 19-12-2022
HGNC name dachsous 1 (Drosophila)
HGNC id 13681
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • twenty seven cadherin repeat domains
  • a unique cytoplasmic region
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,nuclear envelope,int
    text integral plasma membrane,localized at the synaptic junction
    basic FUNCTION
  • may mediate homophilic cell-cell interactions
  • playing a putative role in wound healing
  • FAT4 and DCHS1 cadherins regulate the apical plasma membrane organization in the embryonic cerebral cortex
  • DCHS1 is a component of the membrane domain surrounding the ciliary base, suggesting a specific role of DCHS1 in planar cell polarity-dependent organization of ciliary function and a possible role in lung disease
  • FAT4 and DCHS1 establish polarized cell behaviour intrinsically within the mesenchyme
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • DCHS1-FAT4 is a signalling pathway in osteoblast differentiation
    • a component
  • importance of the FAT4-DCHS1-MPP5 complex in organizing the apical membrane architecture of neural progenitor cells
  • DCHS1-LIX1L-SEPT9 axis interacts with and promotes filamentous actin organization to direct cell-ECM alignment and valve tissue shape
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • unique link between DCHS1-based cell adhesions and the septin-actin cytoskeleton through interactions with LIX1L
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VMLDS1 , MVP2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS