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FLASH GENE
Symbol WNT10A contributors: mct/npt - updated : 22-02-2016
HGNC name wingless-type MMTV integration site family, member 10A
HGNC id 13829
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-linked glycosylation sites
  • an N terminal signal peptide WNT core domain and an RGD motif
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Wnt6
    homolog to C.elegans Y37e11c.A
    homolog to murine Wnt10a
    intraspecies homolog to WNT10B
    Homologene
    FAMILY
  • WNT family
    • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text associated with the extracellular matrix
    basic FUNCTION
  • invoved in oncogenesis and in several developmental process including regulation of cell fate and patterning during embyogenesis
  • playing a key role in carcinogenesis through activation of WNT-beta-catenin-TCF signaling pathway
  • ligand for members of the frizzled family of seven transmembrane receptors
  • plays a crucial role in the development and/or regulation of the ectodermal derivatives
  • key molecule for dentinogenesis and that it is associated with the cell-matrix interactions regulating odontoblast differentiation (Yamashiro 2007)
  • WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism
  • may induce kidney fibrosis and associate with kidney dysfunction in acute interstitial nephritis (AIN)
  • acts as an oncofetal factor that is highly expressed and may promote proper development of the esophagus
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • upstream regulatory molecule for DSPP expression (cell-matrix interaction is essential for induction of DSPP expression) (Yamashiro 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OODD , SSPS , STHAG4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral     --over  
    in cervical cancer
    tumoral     --over  
    in esophageal squamous cell carcinoma
    constitutional     --low  
    affects odontogenesis and proliferation in mesenchymal cells
    Susceptibility to keratoconus
    Variant & Polymorphism SNP
  • rs121908120 increases the risk of keratoconus
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS