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FLASH GENE

Symbol

WNT10A

contributors: mct/npt - updated : 22-02-2016

HGNC name	wingless-type MMTV integration site family, member 10A
HGNC id	13829

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed WNT10A variant 1 - - 3000 - - - 2007 17286598 NM_025216 4 - 2375 NP_079492 46.4 417 - 2007 17286598

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach         Reproductive female system ovary     lowly   male system prostate       Urinary kidney         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage
cell lines	promyelocystic leukemia Burkitt's lymphoma cell lines and strongly coexpressed with WNT6 in colorestal cancer cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, moderatly in kidney, lowly in lung, expressed in the epithelial signaling centers regulating tooth development (Yamashiro 2007)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-linked glycosylation sites
	an N terminal signal peptide WNT core domain and an RGD motif

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Wnt6
	homolog to C.elegans Y37e11c.A
	homolog to murine Wnt10a

intraspecies

homolog to WNT10B

Homologene

FAMILY

WNT family

CATEGORY

protooncogene , signaling

SUBCELLULAR LOCALIZATION	extracellular
text	associated with the extracellular matrix

basic FUNCTION	invoved in oncogenesis and in several developmental process including regulation of cell fate and patterning during embyogenesis
	playing a key role in carcinogenesis through activation of WNT-beta-catenin-TCF signaling pathway
	ligand for members of the frizzled family of seven transmembrane receptors
	plays a crucial role in the development and/or regulation of the ectodermal derivatives
	key molecule for dentinogenesis and that it is associated with the cell-matrix interactions regulating odontoblast differentiation (Yamashiro 2007)
	WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism
	may induce kidney fibrosis and associate with kidney dysfunction in acute interstitial nephritis (AIN)
	acts as an oncofetal factor that is highly expressed and may promote proper development of the esophagus

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

upstream regulatory molecule for DSPP expression (cell-matrix interaction is essential for induction of DSPP expression) (Yamashiro 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

OODD , SSPS , STHAG4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer tumoral     --over   in cervical cancer tumoral     --over   in esophageal squamous cell carcinoma constitutional     --low   affects odontogenesis and proliferation in mesenchymal cells

Susceptibility

to keratoconus

Variant & Polymorphism SNP	rs121908120 increases the risk of keratoconus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS