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FLASH GENE
Symbol VPS45 contributors: mct - updated : 14-06-2011
HGNC name vacuolar protein sorting 45 homolog (S. cerevisiae)
HGNC id 14579
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Vps45
homolog to rattus Vps45a
homolog to Drosophila Cg8228
homolog to yeast S.cerevisiae Vps45p
Homologene
FAMILY
  • SEC1 domain family
  • STXBP/UNC-18/SEC1 family
    • CATEGORY motor/contractile , secretory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • playing a role in trafficking proteins, including inflammatory mediators
  • playing a role in segregation of intracellular molecules into distinct organelles
  • essential for SNARE-mediated membrane trafficking
  • key molecule that functions downstream from RAB5, cooperating with ZFYVE20, to regulate the dynamics of the endocytic system in multicellular organisms
  • playing a role in Golgi-to-lysosome trafficking
  • VPS45 and ZFYVE20 are implicated in post early endosome transport, and their interaction potentially serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation , cellular trafficking transport
    text vesicular transport, inflammatory response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with its cognate SNARE proteins through distinct mechanisms at different stages in the SNARE assembly/disassembly cycle
  • RBSN is a RAB5 effector that bridges an interaction between Rab5 and the Sec1/Munc18-family protein VPS45
  • interacts with the divalent Rab4/Rab5 effector, ZFYVE20 and carries out multiple functions in the endocytic/secretory pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCNP5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS