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FLASH GENE

Symbol

VPS45

contributors: mct - updated : 14-06-2011

HGNC name	vacuolar protein sorting 45 homolog (S. cerevisiae)
HGNC id	14579

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart         Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid         Muscular striatum cardiac

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Vps45
	homolog to rattus Vps45a
	homolog to Drosophila Cg8228
	homolog to yeast S.cerevisiae Vps45p

Homologene

FAMILY	SEC1 domain family
	STXBP/UNC-18/SEC1 family

CATEGORY

motor/contractile , secretory , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	playing a role in trafficking proteins, including inflammatory mediators
	playing a role in segregation of intracellular molecules into distinct organelles
	essential for SNARE-mediated membrane trafficking
	key molecule that functions downstream from RAB5, cooperating with ZFYVE20, to regulate the dynamics of the endocytic system in multicellular organisms
	playing a role in Golgi-to-lysosome trafficking
	VPS45 and ZFYVE20 are implicated in post early endosome transport, and their interaction potentially serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation , cellular trafficking transport

text	vesicular transport, inflammatory response

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interact with its cognate SNARE proteins through distinct mechanisms at different stages in the SNARE assembly/disassembly cycle
	RBSN is a RAB5 effector that bridges an interaction between Rab5 and the Sec1/Munc18-family protein VPS45
	interacts with the divalent Rab4/Rab5 effector, ZFYVE20 and carries out multiple functions in the endocytic/secretory pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCNP5

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS