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FLASH GENE

Symbol

MAP3K10

contributors: mct - updated : 11-04-2023

HGNC name	mitogen-activated protein kinase kinase kinase 10
HGNC id	6849

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   upregulated in pancreatic ductal adenocarcinoma tissues and cell lines constitutional     --over   MAP3K10 methylation in patients with intracranial aneurysm (IA) was significantly lower than that in controls, and this phenomenon was more significant in women

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	MAP3K10 methylation may be a potential predictor of intracranial aneurysm risk, particularly low in women
Therapy target
	System Type Disorder Pubmed cancer digestive pancreas targeting MAP3K10 is a potential strategy for the development of alternative therapies for pancreatic cancers

ANIMAL & CELL MODELS