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FLASH GENE
Symbol TRIM31 contributors: mct/npt - updated : 02-04-2020
HGNC name tripartite motif-containing 31
HGNC id 16289
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in gastric adenocarcinoma
tumoral       gain of function
in Bladder cancer patients when compared with normal subjects
tumoral     --over  
in high-grade glioma tissues
tumoral     --over  
significantly upregulated in liver cancer tissues compared with paired distal non-cancerous liver tissues from HCC patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may be a valuable detective marker in primary colorectal cancer (CRC)
  • independent prognostic factor for glioma patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    TRIM31 may be an effective target for glioma intervention
    cancerdigestiveliver
    potential therapeutic strategy against HCC by targeting TRIM31
    ANIMAL & CELL MODELS
  • Trim31-deficient mice were more susceptible to infection with RNA virus than were wild-type mice