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FLASH GENE
Symbol TRIM31 contributors: mct/npt - updated : 02-04-2020
HGNC name tripartite motif-containing 31
HGNC id 16289
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain type 2
  • a CXXC motif
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • C-terminal PRY and SPRY (Spla kinase and ryanodine receptor) domains (Watanabe 2009)
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Trim31 (52.8 pc)
    homolog to murine Trim31 (54.6 pc)
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • tripartite motif-containing protein (TRIM) family
  • E3 ubiquitin ligase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • associated with the mitochondria and lysosomes as punctate structures
    • basic FUNCTION
  • attenuates SRC1 signaling via p52SHC under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract (Watanabe 2009)
  • had the ability to regulate cell proliferation negatively in gastric adenocarcinoma
  • shows the most rapid kinetics of induction during retinoid-induced growth arrest of breast carcinoma cell (Watanabe 2009)
  • may play an important role in gastrointestinal tissue-specific regulation of cell proliferation (Watanabe 2009)
  • might serve as a tumor suppressor in non-small cell lung cancer
  • TRIM31 expression is tightly controlled in a tissue-specific manner, and expression of TRIM31 may associate with the epithelial function of the intestine mucosa or intestinal immune homoeostasis
  • TRIM31 is involved in the autophagy process
  • TRIM31-induced autophagy is likely essential for restricting the growth of Shigella in epithelial cells
  • TRIM31 limits NLRP3 inflammasome activity under physiological conditions
  • is a potential therapeutic target for the intervention of NLRP3 inflammasome related diseases
  • forms prion-like aggregates to activate an innate antiviral immune response after viral infection 2)
  • mediated chronic inflammation via the NFKB1 pathway to promote invasion and metastasis in colorectal cancer (CRC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacts with SHC1
  • MAGEA1 interaction stimulates TRIM31 ubiquitin-ligase activity
  • considerable interaction between TRIM31 and CALCOCO2
  • TRIM31 is a feedback suppressor of NLRP3 inflammasome
  • TRIM31, an E3 ubiquitin ligase of the TRIM family of proteins, is a regulator of MAVS aggregation
  • TRIM31 exerted its oncogenic effect by directly interacting with the tuberous sclerosis complex (TSC) 1 and TSC2 complex, the upstream suppressor of MTOR pathway
    • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    Other cellular level of TRIM31, is regulated by multiple mechanisms including the ubiquitin-proteasome system
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric adenocarcinoma
    tumoral       gain of function
    in Bladder cancer patients when compared with normal subjects
    tumoral     --over  
    in high-grade glioma tissues
    tumoral     --over  
    significantly upregulated in liver cancer tissues compared with paired distal non-cancerous liver tissues from HCC patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a valuable detective marker in primary colorectal cancer (CRC)
  • independent prognostic factor for glioma patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    TRIM31 may be an effective target for glioma intervention
    cancerdigestiveliver
    potential therapeutic strategy against HCC by targeting TRIM31
    ANIMAL & CELL MODELS
  • Trim31-deficient mice were more susceptible to infection with RNA virus than were wild-type mice