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FLASH GENE

Symbol

TRIM31

contributors: mct/npt - updated : 02-04-2020

HGNC name	tripartite motif-containing 31
HGNC id	16289

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
SPECIAL FEATURE	arranged in tandem
STRUCTURE	10.19 kb     9 Exon(s)    single Copie(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D6S306 - TRIM31 - D6S273 - D6S1615 - cen
Authors	UCSC (2009)

regionally located

located 170 kb centromeric to HLA-A

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007028 9 - 2027 NP_008959 48.1 425 - 2018 29864908

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Homo sapiens   intestine small intestine ileum   highly Homo sapiens   liver       moderately Reproductive male system testis     highly Respiratory lung       moderately   respiratory tract trachea     moderately Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING zinc finger
	a B box domain type 2
	a CXXC motif
	a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
	C-terminal PRY and SPRY (Spla kinase and ryanodine receptor) domains (Watanabe 2009)

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to rattus Trim31 (52.8 pc)
	homolog to murine Trim31 (54.6 pc)

Homologene

FAMILY	B box family, RBCC (TRIM family)
	tripartite motif-containing protein (TRIM) family
	E3 ubiquitin ligase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm,nuclear bodies
text	associated with the mitochondria and lysosomes as punctate structures

basic FUNCTION	attenuates SRC1 signaling via p52SHC under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract (Watanabe 2009)
	had the ability to regulate cell proliferation negatively in gastric adenocarcinoma
	shows the most rapid kinetics of induction during retinoid-induced growth arrest of breast carcinoma cell (Watanabe 2009)
	may play an important role in gastrointestinal tissue-specific regulation of cell proliferation (Watanabe 2009)
	might serve as a tumor suppressor in non-small cell lung cancer
	TRIM31 expression is tightly controlled in a tissue-specific manner, and expression of TRIM31 may associate with the epithelial function of the intestine mucosa or intestinal immune homoeostasis
	TRIM31 is involved in the autophagy process
	TRIM31-induced autophagy is likely essential for restricting the growth of Shigella in epithelial cells
	TRIM31 limits NLRP3 inflammasome activity under physiological conditions
	is a potential therapeutic target for the intervention of NLRP3 inflammasome related diseases
	forms prion-like aggregates to activate an innate antiviral immune response after viral infection 2)
	mediated chronic inflammation via the NFKB1 pathway to promote invasion and metastasis in colorectal cancer (CRC)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interacts with SHC1
	MAGEA1 interaction stimulates TRIM31 ubiquitin-ligase activity
	considerable interaction between TRIM31 and CALCOCO2
	TRIM31 is a feedback suppressor of NLRP3 inflammasome
	TRIM31, an E3 ubiquitin ligase of the TRIM family of proteins, is a regulator of MAVS aggregation
	TRIM31 exerted its oncogenic effect by directly interacting with the tuberous sclerosis complex (TSC) 1 and TSC2 complex, the upstream suppressor of MTOR pathway

cell & other

REGULATION

induced by

IFN-gamma and LPS

Other

cellular level of TRIM31, is regulated by multiple mechanisms including the ubiquitin-proteasome system

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric adenocarcinoma tumoral       gain of function in Bladder cancer patients when compared with normal subjects tumoral     --over   in high-grade glioma tissues tumoral     --over   significantly upregulated in liver cancer tissues compared with paired distal non-cancerous liver tissues from HCC patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a valuable detective marker in primary colorectal cancer (CRC)
	independent prognostic factor for glioma patients
Therapy target
	System Type Disorder Pubmed cancer brain   TRIM31 may be an effective target for glioma intervention cancer digestive liver potential therapeutic strategy against HCC by targeting TRIM31

ANIMAL & CELL MODELS

Trim31-deficient mice were more susceptible to infection with RNA virus than were wild-type mice