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FLASH GENE
Symbol TRIM15 contributors: KTN/npt - updated : 10-02-2009
HGNC name tripartite motif-containing 15
HGNC id 16284
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2241 52 465 - Reymond (2001)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C terminal B30-2/SPRY domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Trim15 (76.3 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentially identifying specific cell compartments
  • acting as an ubiquitin-protein ligase
  • contributing to the endogenous restriction of retroviruses in cells (Uchil 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS