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FLASH GENE

Symbol

TRIM15

contributors: KTN/npt - updated : 10-02-2009

HGNC name	tripartite motif-containing 15
HGNC id	16284

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.49 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D6S464 - D6S306 - TRIM15 - D6S273 - D6S1615 - cen
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TRIM15 7 - 2241 52 465 - Reymond (2001)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING zinc finger
	a B-box domain
	a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
	a C terminal B30-2/SPRY domain

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to murine Trim15 (76.3 pc)

Homologene

FAMILY	TRIM/RBCC family
	C-IV TRIM family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	potentially identifying specific cell compartments
	acting as an ubiquitin-protein ligase
	contributing to the endogenous restriction of retroviruses in cells (Uchil 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS