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FLASH GENE
Symbol TRIM9 contributors: mct - updated : 02-02-2009
HGNC name tripartite motif-containing 9
HGNC id 16288
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a COS (C-terminal subgroup one signature) domain
  • a FN3 (fibronectin type-3) domain
  • a C terminal B30-2/SPRY domain
  • RFP-like domain
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Trim9 (97.8 pc)
    homolog to murine Trim9 (97.1 pc)
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • C-I TRIM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • cytoplasmic bodies
  • in cytoplasmic speckles
    • basic FUNCTION
  • may act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with SNAP25
  • interactions between TRIM9 and UBE2G2 (TRIM E3 activity is only manifest with the UBE2 with which they interact)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS