SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| text
| cytosolic protein, with a significant portion associated with small, punctate membrane structures, also present in membrane ruffles and lamellipodia |
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colocalization with the centrosomal markers gamma-tubulin and A kinase anchoring protein (AKAP-450) |
| basic FUNCTION
| involved in the endosomal dynamics and probably also in the control of nuclear organization |
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implicated in intracellular membrane trafficking or microtubule dynamics |
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may be involved in membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling |
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promoting neurite outgrowth, playing an essential role in the maintenance of motor neurons |
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may act as a modulator in neuronal differentiation and/or development through regulation of membrane dynamics |
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acting as a guanine nucleotide exchange factor (GEF) for the small GTPase Rab5 and is implicated in endosome dynamics in cells |
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contributes to macropinocytosis and is implicated in axonal growth in neurons |
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negatively regulatory mechanism of ALS2 in RAB5-mediated endosomal traffickingb  |
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plays a role in neuroprotection against motor neuron diseases-associated pathological insults, such as toxicity induced by mutant SOD1 |
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potentially implicated in endolysosomal trafficking through the fusion between endosomes and autophagosomes, thereby regulating endolysosomal protein degradation |
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potentially playing a role in a certain intracellular signal transduction pathway and/or a cytoplasmic transport system |
