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FLASH GENE
Symbol TRIM2 contributors: mct - updated : 08-02-2012
HGNC name tripartite motif-containing 2
HGNC id 15974
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a FIL (filamin-type immunoglobulin) domain
  • a NHL domain
    • HOMOLOGY
    Homologene
    FAMILY
  • C-VII TRIM family
  • B box family, RBCC (TRIM family)
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text filaments
    basic FUNCTION
  • ubiquitin-protein ligase, involved in cancerogenesis and the defense against viral infection
  • important function of TRIM2 for axon outgrowth during development
  • RING (really interesting new gene) domain-containing protein
  • role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of BCL2L11 in rapid ischemic tolerance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • binds to neurofilament light subunit (NF-L) and regulates NF-L ubiquitination
  • binds to BCL2L11 when it is phosphorylated by p42/p44 MAPK
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2R
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    neurodegeneration in Trim2GT mutant mice is accompanied by axonal swelling and accumulation of NF-L