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FLASH GENE
Symbol TRIM2 contributors: mct - updated : 08-02-2012
HGNC name tripartite motif-containing 2
HGNC id 15974
Corresponding disease
CMT2R Charcot-Marie-Tooth disease, type 2R
Location 4q31.3      Physical location : 154.074.269 - 154.260.474
Synonym name KIAA0517 protein
Synonym symbol(s) KIAA0517, RNF86
DNA
TYPE functioning gene
STRUCTURE 186.20 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC283341 4q31.23 similar to Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase) RPS3A 4q31.2-q31.3 ribosomal protein S3A U73B 4q31.2-q31.3 RNA, U73B small nucleolar DKFZp434D0215 4q31.23 SH3 domain protein D19 LOC391704 4 similar to Prss32 protein ESSPL 4q31.23 epidermis-specific serine protease-like protein LOC391705 4 similar to RIKEN cDNA 9930021J17 PET112L 4q27-q28 PET112-like (yeast) LOC389232 4 LOC389232 LOC389233 4 LOC389233 FBXW7 4q31.23 F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) LOC391706 4 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 FLJ32028 4q31.3 hypothetical protein FLJ32028 TIGD4 4q31.23 tigger transposable element derived 4 ARFIP1 4q31.3 ADP-ribosylation factor interacting protein 1 (arfaptin 1) LOC152667 4q31.3 similar to NEFA-interacting nuclear protein NIP30 KIAA1727 4q31.3 KIAA1727 protein LOC389234 4 LOC389234 TRIM2 4q31.3 tripartite motif-containing 2 ANXA2P1 4q21-q31 annexin A2 pseudogene 1 GAJ 4q31.3 GAJ protein KIAA0922 4q31.23 GAJ protein LOC285532 4q31.3 similar to JM5 protein TLR2 4q32 toll-like receptor 2 LOC285533 4q31.3 hypothetical protein LOC285533 SFRP2 4q31.3 secreted frizzled-related protein 2 FLJ20047 4q31.3 hypothetical protein FLJ20047 LOC389235 4 similar to protocadherin 16 precursor; fibroblast cadherin FIB1; fibroblast cadherin 1; dachsous homologue PLRG1 4q31.2-q32.1 pleiotropic regulator 1 (PRL1homolog, Arabidopsis) FGB 4q28 fibrinogen, B beta polypeptide FGA 4q28 fibrinogen, A alpha polypeptide FGG 4q28 fibrinogen, G gamma polypeptide LRAT 4q31.1-q31.23 lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) MGC27016 4q31.3 hypothetical protein MGC27016 LOC389236 4 LOC389236 NPY2R 4q31 neuropeptide Y receptor Y2 LOC389237 4 LOC389237 FLJ21159 4q31.3 hypothetical protein FLJ21159 GUCY1A3 4q31.1-q31.2 guanylate cyclase 1, soluble, alpha 3 GUCY1B3 4q31.3-q33 guanylate cyclase 1, soluble, beta 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 6757 - 771 - 2011 20796172
12 - 6792 - 744 - 2011 20796172
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
Nervousbrainlimbic systemhippocampus highly Homo sapiens
 nerve   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a FIL (filamin-type immunoglobulin) domain
  • a NHL domain
  • HOMOLOGY
    Homologene
    FAMILY
  • C-VII TRIM family
  • B box family, RBCC (TRIM family)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text filaments
    basic FUNCTION
  • ubiquitin-protein ligase, involved in cancerogenesis and the defense against viral infection
  • important function of TRIM2 for axon outgrowth during development
  • RING (really interesting new gene) domain-containing protein
  • role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of BCL2L11 in rapid ischemic tolerance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • binds to neurofilament light subunit (NF-L) and regulates NF-L ubiquitination
  • binds to BCL2L11 when it is phosphorylated by p42/p44 MAPK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2R
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    neurodegeneration in Trim2GT mutant mice is accompanied by axonal swelling and accumulation of NF-L