SUBCELLULAR LOCALIZATION
| intracellular
|
|
| intracellular,cytoplasm,organelle,mitochondria
|
|
| intracellular,nucleus,chromatin/chromosome
|
|
| intracellular,nucleus,nucleolus
|
| text
| cross-dependence between aprataxin and nucleolin in the nucleolus and its nucleolar localization is dependent on rRNA synthesis |
|
localizes to mitochondria in human cells  |
|
Purkinje cells had both nuclear and cytoplasmic aprataxin |
| basic FUNCTION
| involved in DNA repair in the nucleolus, through its interactions with deadenylating XRCC1 and/or other components of DNA repair |
|
influencing the cellular response to genotoxic stress very likely by its capacity to interact with a number of proteins involved in DNA repair |
|
may have a general proofreading function in DNA repair, removing DNA adenylates as they arise during single-strand break repair, double-strand break repair, and in base excision repair |
|
having an important and direct role in single-strand break repair, that is, it removes blocking molecules from DNA 3'-ends |
|
first protein to adopt canonical histidine triad-type reaction chemistry for the repair of DNA |
|
possesses nick sensor activity, which is ideally suited to locate and repair 5'-DNA adenylates |
|
direct and indirect modulating functions on base excision repair |
|
catalyzes removal of adenosine monophosphate (AMP) from the 5 prime end of a DNA strand, which results from an aborted attempt to ligate a strand break containing a damaged end |
|
having potentially a direct role in mtDNA processing |
|
plays an important role in the repair of mtDNA and that defects in aprataxin expression and/or function lead to mitochondrial dysfunction and oxidative stress |
|
role of TDP1 and APTX in mitochondrial DNA repair |
