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FLASH GENE
Symbol GDAP1 contributors: mct - updated : 30-08-2013
HGNC name ganglioside-induced differentiation-associated protein 1
HGNC id 15968
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glutathione S-transferase N terminal domain
  • transmembrane domains necessary for the localization in mitochondria
  • two putative transmembrane domains
  • GST-like domain, glutathione S-transferase C terminal domain
  • secondary structure alpha helical domain 2
    HOMOLOGY
    interspecies homolog to murine Gdap1
    Homologene
    FAMILY
  • GST superfamily
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • located in the outer mitochondrial membrane and induces fragmentation of mitochondria
  • basic FUNCTION
  • may be functioning in a signal transduction pathway responsible for ganglioside-induced neurite
  • differentiation
  • may be related to the maintenance of the mitochondrial network
  • may have a role in the fission pathway of the mitochondrial dynamics
  • mitochondrial fission factor whose activity is dependent on the fission factors CRMP1 and FIS1
  • promotes fission without increasing the risk of apoptosis
  • essential for the viability of cells in the peripheral nervous system
  • novel function of GDAP1 in the defense against oxidative stress
  • might act as a glutathione sensor, which transmits information about the cytosolic glutathione content through its GST-like domains to the mitochondria, leading to changes in mitochondrial form and function
  • tail-anchored protein of mitochondria and induces mitochondrial fragmentation
  • regulates mitochondrial and peroxisomal fission by a similar mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neuronal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with YY1 (YY1 acts to induce GDAP1 gene expression, decreasing YY1 levels should repress it)
  • interacts with the vesicle-organelle trafficking proteins RAB6B, suggesting that GDAP1 may participate in the mitochondrial movement within the cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT4A , CMT2K
    related resource Mutation Database of Inherited Peripheral Neuropathies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS