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FLASH GENE
Symbol SLC16A8 contributors: mct/npt - updated : 26-03-2020
HGNC name solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
HGNC id 16270
Location 22q13.1      Physical location : 38.474.144 - 38.479.170
Synonym name
  • monocarboxylate transporter 3
  • solute carrier 16 (monocarboxylic acid transporters), member 8
    • Synonym symbol(s) MCT3, REMP
    DNA
    TYPE functioning gene
    STRUCTURE 6.05 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located between markers WI11639 and SGC30687
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1913 - 504 - 2004 12739169
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Slc16a8
    homolog to rattus Slc16a8
    intraspecies homolog to SLC16A3
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text preferentially expressed in the basolateral membrane of the retinal pigment epithelium (Daniele 2008)
    basic FUNCTION
  • proton-coupled transporter
  • transport of lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
  • proton-coupled monocarboxylate transporter, critically positioned to facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (
  • disruption of SLC16A18 leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text small molecule transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
  • forms a heteromeric complex with the accessory protein CD147 (Daniele 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current (Daniele 2008)
    constitutional germinal mutation      
    associated with severe psychomotor retardation and triiodothyronine T3 levels (Visser 2008)
    Susceptibility to age-related macular degeneration (AMD)
    Variant & Polymorphism other
  • expression level of SLC16A8 was significantly associated with AMD pathology
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS