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FLASH GENE
Symbol TRIM54 contributors: mct/ - updated : 31-03-2007
HGNC name tripartite motif-containing 54
HGNC id 16008
Location 2p23.3      Physical location : 27.505.296 - 27.530.306
Synonym name
  • muscle-specific RING-finger protein homolog
  • ring finger protein 30
    • Synonym symbol(s) MURF3, MURF-3, RNF30
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 25.01 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2073 - 400 - 2001 11243782
    9 - 1947 - 358 - 2001 11243782
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Lymphoid/Immunetonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved N-terminal Ring finger motif
  • a zinc-binding type-2 B-box motif
  • a coiled coil dimerization motif box in the central region (RBCC)
  • a COS (C-terminal subgroup one signature) domain
  • a tripartite motif (TRIM)
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Rnf30
    Homologene
    FAMILY
  • C-II TRIM family
  • MURF subfamily
  • RBCC family
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    text colocalized with microtubules and Z-lines in skeletal muscles
    basic FUNCTION
  • playing a potential role in skeletal myoblast differentiation and myotube fusion
  • affecting microtubules stabiliting
  • striated muscle-restricted components of the sarcomere that are thought to possess ubiquitin ligase activity
  • playing an important role in maintaining cardiac integrity and function after acute myocardial infarction
    • CELLULAR PROCESS cell cycle, division
    cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with FHL2 and gamma-filamin (controlling the degradation of FHL2 and FLNC)
    • cell & other
  • microtubules
    • REGULATION
    Other upregulated during striated muscle development
    regulated by IGF2BP2 (regulates the expression of LIMS2 and TRIM54 proteins via direct binding to their mRNAs)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    resulting in accumulation of FHL2 and FLNC, widening of the sarcomere, diminished contractility and susceptibility to ventricular rupture
    Susceptibility to cardiac rupture after myocardial infarction
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS