| basic FUNCTION
| sarcomere-associated protein, involved in the cell cycle regulatory process of striated muscle cells |
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playing a role in striated muscle cell embryonic development |
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may coordinately regulate the energy metabolism of mitochondrial and cytoplasmic compartments |
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acting as an E3 ubiquitin ligase (Ozato 2008) |
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regulating proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins |
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may regulate the organization of myofibrils through TTN in muscle cells |
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involved in regulating muscle trophic homeostasis through interactions with a number of proteins including glycogen phosphorylase and FOXO (Forkhead box, subgroup O) |
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plays an important role in regulating cardiac size through alterations in protein turnover and that MuRF1 is not required to induce cardiac atrophy  |
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muscle RING finger protein which is involved in muscle wasting |
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is involved in disuse-induced bone loss in both of the two major bone remodeling activities, osteoblastic bone formation and osteoclastic bone resorption |
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is responsible for mediating muscle atrophy that occurs during the period of active lung injury in humans, and skeletal muscle dysfunction persists despite resolution of lung injury |
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FBXO32 and TRIM63 are two E3 ubiquitin ligases that are important regulators of ubiquitin-mediated protein degradation in skeletal muscle |
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maintains muscle protein homeostasis by tagging the sarcomere proteins with ubiquitin for subsequent degradation by the ubiquitin-proteasome system (UPS) |
