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FLASH GENE

Symbol

PRLHR

contributors: - updated : 17-03-2006

HGNC name	prolactin releasing hormone receptor
HGNC id	4464

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to Chimpanzee GPR10
	ortholog to murine Prlhr
	ortholog to rattus Gpr10

intraspecies	homolog to NPYR1
	homolog to NPY2R

Homologene

FAMILY

G protein coupled receptor 1 family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	having neuropeptide Y receptor, rhodopsin-like receptor activities
	implicated in the central control of lactation, appetite and blood pressure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

receptor for NPY, PYY

cell & other

REGULATION

repressed by

by bromocriptine (requiring CREB )

Other

regulated by forskolin

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   highly expressed in pheochromocytomas, suggesting potential pathophysiological roles of PrRP in these tumors

Susceptibility

to abnormal blood pressure

Variant & Polymorphism other	P305L associated with abnormal blood pressure

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	beginning at 16 weeks of age on a normal diet, mice lacking Prlhr overate, became obese, had increased body fat as well as leptin and insulin levels, and showed decreased glucose tolerance
	Prlhr -/- mice had higher nociceptive thresholds and stronger stress-induced analgesia than wildtype mice, and that these differences could be suppressed by naloxone