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FLASH GENE
Symbol PRLHR contributors: - updated : 17-03-2006
HGNC name prolactin releasing hormone receptor
HGNC id 4464
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     1 Exon(s)
regulatory sequence Promoter
Binding site   silencer   transcription factor
text structure
  • several putative binding site for PIT1, Sp1, AP-1
  • a putative NRSE (neuron-restrictive silencer element) located in the 5' promoter region
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     neuroendocrinepituitary  highly
    nervousbraindiencephalon   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Chimpanzee GPR10
    ortholog to murine Prlhr
    ortholog to rattus Gpr10
    intraspecies homolog to NPYR1
    homolog to NPY2R
    Homologene
    FAMILY G protein coupled receptor 1 family
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having neuropeptide Y receptor, rhodopsin-like receptor activities
  • implicated in the central control of lactation, appetite and blood pressure
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for NPY, PYY
    • cell & other
    REGULATION
    repressed by by bromocriptine (requiring CREB )
    Other regulated by forskolin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in pheochromocytomas, suggesting potential pathophysiological roles of PrRP in these tumors
    Susceptibility to abnormal blood pressure
    Variant & Polymorphism other P305L associated with abnormal blood pressure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • beginning at 16 weeks of age on a normal diet, mice lacking Prlhr overate, became obese, had increased body fat as well as leptin and insulin levels, and showed decreased glucose tolerance
  • Prlhr -/- mice had higher nociceptive thresholds and stronger stress-induced analgesia than wildtype mice, and that these differences could be suppressed by naloxone