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FLASH GENE

Symbol

PPP1R16A

contributors: mct/ - updated : 26-06-2012

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 16A
HGNC id	14941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q24.3      Physical location : 145.722.108 - 145.727.503
Synonym name	myosin phosphatase targeting subunit 3
Synonym symbol(s)	MYPT3, MGC14333, R16A

DNA

TYPE	functioning gene
STRUCTURE	5.66 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032902 10 - 2326 NP_116291 - 528 - 2008 18202305

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Homo sapiens Endocrine pancreas       highly Nervous brain       highly Reproductive male system testis     highly Homo sapiens Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Reproductive sperm cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ankyrin repeats at the N terminus and a consensus PP1-binding site, binding OAZ3 p12
	a unique C terminal region containing several potential signaling motifs and a CaaX prenylation site (where AA indicates aliphatic amino acid) box at the C termini

mono polymer

dimer

HOMOLOGY

interspecies

homolog to murine Ppp1r16a

Homologene

FAMILY	myosin phosphatase targeting subunit (MYPT) family
	nuclear steroid/thyroid hormone receptor family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	myosin-binding targeting subunits of protein phosphatase 1 (PPP1c)
	its phosphorylation may play an important role in regulating PP1c catalytic activity
	constitutive active/androstane receptor-binding protein
	may mediate the phenobarbital signal to initiate constitutive active/androstane receptor nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

can form dimer through its middle region, where protein kinase A phosphorylation sites are recently identified

INTERACTION

DNA

RNA

small molecule

protein	PP1
	can be a substrate for protein kinase A (PRKACA)
	can bind protein phosphatase PPP1CC, the only protein phosphatase present in sperm tails, and p12- PPP1R16A interaction modulates the activity of PPP1CC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS