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FLASH GENE
Symbol PPP1R14C contributors: npt/SGE - updated : 04-02-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 14C
HGNC id 14952
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • consensus seqences for phosphorylation by PKC, PKA, casein kinase III
  • multiple N terminal myristoylation consensus sites
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ppp1r14c (91.5pc)
    homolog to rattus Ppp1r14c (92.1pc)
    Homologene
    FAMILY
  • PP1 inhibitor family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibiting PP1CA
  • inhibitor of ser/thr phosphatase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
    • cell & other
    REGULATION
    activated by upregulated by both acute and chronic morphine treatments
    Other exhibits a 600-fold higher inhibitory activity when phospohrylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • detected in breast cancer
    • Marker
    Therapy target
    ANIMAL & CELL MODELS