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FLASH GENE

Symbol

PPP1R14C

contributors: npt/SGE - updated : 04-02-2010

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 14C
HGNC id	14952

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	107.34 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030949 4 - 2211 NP_112211 17.7 165 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain forebrain cerebral cortex       brain diencephalon hypothalamus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	consensus seqences for phosphorylation by PKC, PKA, casein kinase III
	multiple N terminal myristoylation consensus sites

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Ppp1r14c (91.5pc)
	homolog to rattus Ppp1r14c (92.1pc)

Homologene

FAMILY

PP1 inhibitor family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	inhibiting PP1CA
	inhibitor of ser/thr phosphatase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

PP1

cell & other

REGULATION

activated by

upregulated by both acute and chronic morphine treatments

Other

exhibits a 600-fold higher inhibitory activity when phospohrylated

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	detected in breast cancer
Marker
Therapy target

ANIMAL & CELL MODELS