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FLASH GENE
Symbol PPP1R14C contributors: npt/SGE - updated : 04-02-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 14C
HGNC id 14952
Location 6q25.1      Physical location : 150.464.187 - 150.571.526
Synonym name
  • serologically defined breast cancer antigen NY-BR-81
  • PKC-potentiated PP1 inhibitory protein
  • kinase C-enhanced PP1 inhibitor
    • Synonym symbol(s) NY-BR-81, CPI17-like, KEPI
    EC.number 2.7.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 107.34 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2211 17.7 165 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrainforebraincerebral cortex  
     braindiencephalonhypothalamus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • consensus seqences for phosphorylation by PKC, PKA, casein kinase III
  • multiple N terminal myristoylation consensus sites
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ppp1r14c (91.5pc)
    homolog to rattus Ppp1r14c (92.1pc)
    Homologene
    FAMILY
  • PP1 inhibitor family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibiting PP1CA
  • inhibitor of ser/thr phosphatase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
    • cell & other
    REGULATION
    activated by upregulated by both acute and chronic morphine treatments
    Other exhibits a 600-fold higher inhibitory activity when phospohrylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • detected in breast cancer
    • Marker
    Therapy target
    ANIMAL & CELL MODELS