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FLASH GENE

Symbol

ZFHX3

contributors: mct/npt - updated : 27-02-2024

HGNC name	zinc finger homeobox 3
HGNC id	777

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCA4 , ATFB8 , IDASDB

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in prostate cancer tumoral     --low   in breast cancers with poor prognosis tumoral     --over   and this up-regulation correlated with both HIF1A up-regulation and worse patient survival, confirming a functional association between ZFHX3 and HIF1A in human hepatocellular carcinoma (HCC)

Susceptibility

to atrial fibrillation (AF) to Kawasaki disease (KD)

Variant & Polymorphism SNP	rs7193343-T, associated significantly with AF
	rs7199343 significantly associated to KS (Burgner 2009)
	rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population

Candidate gene	ZFHX3, MACF1, RBM15, and SETD2 are Orofacial cleft candidate risk genes
Marker
Therapy target
	System Type Disorder Pubmed respiratory lung chr.Bronchopathy obstructive therapeutic targets to interrupt hypercapnic immunosuppression in patients with advanced lung disease

ANIMAL & CELL MODELS

in mouse mammary tissue, knock-out of Zfhx3 interrupted lactogenesis, resulting in underdeveloped glands with much smaller and fewer alveoli