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FLASH GENE

Symbol

PPP1R12C

contributors: npt/mct - updated : 03-11-2010

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 12C
HGNC id	14947

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	26.66 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017607 22 - 2942 NP_060077 84.7 782 - 2001 11399775

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal ankyrin repeats
	a centrally located conserved motif
	the MRCK alpha-kinase phosphorylation site
	C terminal leucine repeats
	an alpha-helical C terminus

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	regulating PP1 delta catalytic activities
	regulating the assembly of actin cytoskeleton
	regulate various contractile processes in muscle and non-muscle cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PP1 delta
	MPRIP is an actin-binding protein that interacts with PPP1R12C

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS