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FLASH GENE
Symbol PPP1R12C contributors: npt/mct - updated : 03-11-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 12C
HGNC id 14947
Location 19q13.42      Physical location : 55.602.282 - 55.628.927
Synonym name
  • myosin binding subunit 85
  • leukocyte receptor cluster (LRC) member 3
  • protein phosphatase 1 myosin-binding subunit p85
    • Synonym symbol(s) p84, LENG3, DKFZP434D0412, MBS85
    DNA
    TYPE functioning gene
    STRUCTURE 26.66 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2942 84.7 782 - 2001 11399775
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal ankyrin repeats
  • a centrally located conserved motif
  • the MRCK alpha-kinase phosphorylation site
  • C terminal leucine repeats
  • an alpha-helical C terminus
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulating PP1 delta catalytic activities
  • regulating the assembly of actin cytoskeleton
  • regulate various contractile processes in muscle and non-muscle cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1 delta
  • MPRIP is an actin-binding protein that interacts with PPP1R12C
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS