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FLASH GENE
Symbol ST8SIA1 contributors: mlc - updated : 27-10-2007
HGNC name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
HGNC id 10869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • single transmembrane segment (TM)
  • four common sequence regions of vertebrate sialyltransferases, referred to as the L, S, III, and VS sialylmotifs, identified in all vertebrate sialyltransferases and playing important roles in spatial structure maintenance and protein functions
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Siat8a
    homolog to C.elegans B0412.2
    Homologene
    FAMILY
  • vertebrate sialyltransferase family
  • glycosyltransferase family 29
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • Golgi (potential)
    • basic FUNCTION
  • converting the ganglioside GM3 to GD3 and GT3
  • involved in gene regulation
  • catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    text glycosylation
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosphingolipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS