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FLASH GENE

Symbol

ST8SIA1

contributors: mlc - updated : 27-10-2007

HGNC name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
HGNC id	10869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	133.00 kb     5 Exon(s)

regulatory sequence	Promoter
	Binding site   silencer
motif	repetitive sequence
text structure	SP1 binding site(s)
	a silencer region between -2262 and -978 nt
	a GT/CG repeat sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 2117 - 356 - Ko

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine parathyroid       highly   thyroid       highly Respiratory lung       lowly

cell lineage
cell lines	highly in melanoma cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	highly in brain, lowly in lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	single transmembrane segment (TM)
	four common sequence regions of vertebrate sialyltransferases, referred to as the L, S, III, and VS sialylmotifs, identified in all vertebrate sialyltransferases and playing important roles in spatial structure maintenance and protein functions

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Siat8a
	homolog to C.elegans B0412.2

Homologene

FAMILY	vertebrate sialyltransferase family
	glycosyltransferase family 29

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein
	Golgi (potential)

basic FUNCTION	converting the ganglioside GM3 to GD3 and GT3
	involved in gene regulation
	catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

text	glycosylation

PATHWAY

metabolism

carbohydrate

signaling

glycosphingolipid biosynthesis

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS