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FLASH GENE
Symbol ST8SIA1 contributors: mlc - updated : 27-10-2007
HGNC name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
HGNC id 10869
Location 12p12.1-p11.2      Physical location : 22.346.325 - 22.487.648
Synonym name
  • ganglioside GD3 synthase
  • sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)
    • Synonym symbol(s) GD3S, SIAT8, ST8SIA-I, SIAT8A, ST8Sia I, ST8SiaI
    EC.number 2.4.99.8
    DNA
    TYPE functioning gene
    STRUCTURE 133.00 kb     5 Exon(s)
    regulatory sequence Promoter
    Binding site   silencer
    motif repetitive sequence
    text structure
  • SP1 binding site(s)
  • a silencer region between -2262 and -978 nt
  • a GT/CG repeat sequence
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2117 - 356 - Ko
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
     thyroid   highly
    Respiratorylung   lowly
    cell lineage
    cell lines highly in melanoma cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in brain, lowly in lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • single transmembrane segment (TM)
  • four common sequence regions of vertebrate sialyltransferases, referred to as the L, S, III, and VS sialylmotifs, identified in all vertebrate sialyltransferases and playing important roles in spatial structure maintenance and protein functions
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Siat8a
    homolog to C.elegans B0412.2
    Homologene
    FAMILY
  • vertebrate sialyltransferase family
  • glycosyltransferase family 29
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • Golgi (potential)
    • basic FUNCTION
  • converting the ganglioside GM3 to GD3 and GT3
  • involved in gene regulation
  • catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    text glycosylation
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosphingolipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS