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FLASH GENE

Symbol

PPP1R1B

contributors: mct/npt - updated : 19-07-2008

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
HGNC id	9287

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in leukoplakia, and oral squamous cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	regulation of the nuclear accumulation of PPP1R1B may be important to the functions or dysfunctions of dopamine that involve transcription-dependent long-term plasticity, including neuroleptic- and L-DOPA-induced dyskinesia, and other diseases of the basal ganglia

ANIMAL & CELL MODELS

Darpp 32 knockout mice