SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus,nucleoplasm
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| intracellular,nuclear envelope,int
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| intracellular,nuclear envelope,ext
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| text
| inner and outer membrane of nucleus |
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predominantly mitochondrial |
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primarily a mitochondrial protein, localized to the mitochondrial matrix |
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core mitochondrial nucleiod protein  |
| basic FUNCTION
| RNA-binding protein that is a constituent of postsplicing nuclear RNP complexes associated with mature mRNA |
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multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling |
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involved in integration of cytoskeletal networks with vesicular trafficking, nucleocytosolic shutting, chromosome remodeling |
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participating in mRNA processing both in the nucleus and the mitochondrion |
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having a role in transcription of the ABCB1 and MVP genes |
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may function as a chaperone involved in the assembly of mitochondrial complex IV, although it also binds nucleic acids |
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required for the nuclear export arm of the regulon may function as energy sensors in the cell, coupling proliferation and survival to energy status |
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involved in the expression of genes related to hexose metabolism, prostaglandin synthesis and glycosphingolipid biology that may either play an adaptive role in cell survival or contribute to LSFC pathogenesis |
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plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase subunits |
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activates mitochondrial transcription, activation that is associated with remodeling of mitochondria |
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stimulates oxidative phosphorylation |
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stimulates OXPHOS by promoting supercomplex formation, which increases cristae density |
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transcriptional activator of mitochondrial transcription |
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LRPPRC forms an RNA-dependent protein complex that is necessary for maintaining a pool of non-translated mRNAs in mammalian mitochondria |
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acts at the post-transcriptional level to stabilize mitochondrial mRNAs, to promote mitochondrial mRNA polyadenylation, and to coordinate mitochondrial translation |
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LRPPRC does not directly regulate mtDNA transcription but rather acts as a post-transcriptional regulator of mammalian mtDNA expression |
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LRPPRC functions as a checkpoint protein that prevents mitochondria from autophagy degradation and impact tumorigenesis |
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multi-functional protein, that regulates a myriad of biological processes, including energy metabolism and maturation and the export of nuclear mRNA |
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LRPPRC acted as an inhibitor of autophagy in human cancer cells |
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LRPPRC may act as an oncogene via maintaining mitochondrial homeostasis |
