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FLASH GENE
Symbol ECI2 contributors: npt/shn - updated : 30-05-2013
HGNC name enoyl-CoA delta isomerase 2
HGNC id 14601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • type-1 peroxisomal targeting signals
    • HOMOLOGY
    interspecies ortholog to Eci2, Mus musculus
    ortholog to ECI2, Pan troglodytes
    ortholog to Eci2, Rattus norvegicus
    Homologene
    FAMILY
  • ACBP family
  • enoyl-CoA hydratase/isomerase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,peroxisome
    text present in the peroxisomes of human hepatocytes
    basic FUNCTION
  • delta (3)-cis-delta (2)-trans-enoyl-CoA isomerase
  • isomerizing both 3-cis and 3 transdouble bonds into the 2-transform in a range of enoyl-CoA species
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid, fatty-acid and sterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers with WNT10A
    tumoral     --over  
    in cervical cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS