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FLASH GENE
Symbol ECI2 contributors: npt/shn - updated : 30-05-2013
HGNC name enoyl-CoA delta isomerase 2
HGNC id 14601
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 1410 - 364 - -
10 splicing 1420 - 394 - -
11 splicing 1481 - - - -
non-coding RNA.
10 splicing 1422 - 364 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiensAdult
Digestiveintestinesmall intestine  lowly Homo sapiensAdult
 intestinelarge intestinecolon lowly Homo sapiensAdult
 liver   highly Homo sapiensAdult
Endocrinepancreas   highly Homo sapiensAdult
Lymphoid/Immunespleen   lowly Homo sapiensAdult
 thymus   moderately Homo sapiensAdult
 thymus   lowly Homo sapiensAdult
Nervousbrain   lowly Homo sapiensAdult
Reproductivefemale systemplacenta  lowly Homo sapiensAdult
 female systemovary  moderately Homo sapiensAdult
 male systemprostate  moderately Homo sapiensAdult
Respiratorylung   lowly Homo sapiensAdult
Urinarykidney   highly Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • type-1 peroxisomal targeting signals
  • HOMOLOGY
    interspecies ortholog to Eci2, Mus musculus
    ortholog to ECI2, Pan troglodytes
    ortholog to Eci2, Rattus norvegicus
    Homologene
    FAMILY
  • ACBP family
  • enoyl-CoA hydratase/isomerase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,peroxisome
    text present in the peroxisomes of human hepatocytes
    basic FUNCTION
  • delta (3)-cis-delta (2)-trans-enoyl-CoA isomerase
  • isomerizing both 3-cis and 3 transdouble bonds into the 2-transform in a range of enoyl-CoA species
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid, fatty-acid and sterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers with WNT10A
    tumoral     --over  
    in cervical cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS