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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ECI2

contributors: npt/shn - updated : 30-05-2013

HGNC name	enoyl-CoA delta isomerase 2
HGNC id	14601

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	19.90 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006117.2 10 splicing 1410 NP_006108 - 364 - - NM_206836.2 10 splicing 1420 NP_996667 - 394 - - NR_028588.1 11 splicing 1481 - - - - non-coding RNA. NM_001166010.1 10 splicing 1422 NP_001159482 - 364 - -

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Adult Digestive intestine small intestine     lowly Homo sapiens Adult   intestine large intestine colon   lowly Homo sapiens Adult   liver       highly Homo sapiens Adult Endocrine pancreas       highly Homo sapiens Adult Lymphoid/Immune spleen       lowly Homo sapiens Adult   thymus       moderately Homo sapiens Adult   thymus       lowly Homo sapiens Adult Nervous brain       lowly Homo sapiens Adult Reproductive female system placenta     lowly Homo sapiens Adult   female system ovary     moderately Homo sapiens Adult   male system prostate     moderately Homo sapiens Adult Respiratory lung       lowly Homo sapiens Adult Urinary kidney       highly Homo sapiens Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

type-1 peroxisomal targeting signals

HOMOLOGY

interspecies	ortholog to Eci2, Mus musculus
	ortholog to ECI2, Pan troglodytes
	ortholog to Eci2, Rattus norvegicus

Homologene

FAMILY	ACBP family
	enoyl-CoA hydratase/isomerase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,peroxisome
text	present in the peroxisomes of human hepatocytes

basic FUNCTION	delta (3)-cis-delta (2)-trans-enoyl-CoA isomerase
	isomerizing both 3-cis and 3 transdouble bonds into the 2-transform in a range of enoyl-CoA species

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

lipid, fatty-acid and sterol metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancers with WNT10A tumoral     --over   in cervical cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS