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FLASH GENE
Symbol ECI2 contributors: npt/shn - updated : 30-05-2013
HGNC name enoyl-CoA delta isomerase 2
HGNC id 14601
Location 6p25.1      Physical location : -
Synonym name
  • peroxisomal D3,D2-enoyl-CoA isomerase
  • D3,D2-enoyl-CoA isomerase
  • DBI-related protein 1
  • diazepam-binding inhibitor-related protein 1
  • dodecenoyl-CoA isomerase
  • hepatocellular carcinoma-associated antigen 88
  • renal carcinoma antigen NY-REN-1
  • acyl-Coenzyme A binding domain containing 2
  • enoyl-CoA delta isomerase 2, mitochondrial
  • delta(3),delta(2)-enoyl-CoA isomerase
  • peroxisomal 3,2-trans-enoyl-CoA isomerase
    • Synonym symbol(s) ACBD2, DRS1, HCA88, KIAA0536, dJ1013A10.3, DRS-1, PECI
    EC.number 5.3.3.8
    DNA
    TYPE functioning gene
    STRUCTURE 19.90 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 1410 - 364 - -
    10 splicing 1420 - 394 - -
    11 splicing 1481 - - - -
    non-coding RNA.
    10 splicing 1422 - 364 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensAdult
    Digestiveintestinesmall intestine  lowly Homo sapiensAdult
     intestinelarge intestinecolon lowly Homo sapiensAdult
     liver   highly Homo sapiensAdult
    Endocrinepancreas   highly Homo sapiensAdult
    Lymphoid/Immunespleen   lowly Homo sapiensAdult
     thymus   moderately Homo sapiensAdult
     thymus   lowly Homo sapiensAdult
    Nervousbrain   lowly Homo sapiensAdult
    Reproductivefemale systemplacenta  lowly Homo sapiensAdult
     female systemovary  moderately Homo sapiensAdult
     male systemprostate  moderately Homo sapiensAdult
    Respiratorylung   lowly Homo sapiensAdult
    Urinarykidney   highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • type-1 peroxisomal targeting signals
    • HOMOLOGY
    interspecies ortholog to Eci2, Mus musculus
    ortholog to ECI2, Pan troglodytes
    ortholog to Eci2, Rattus norvegicus
    Homologene
    FAMILY
  • ACBP family
  • enoyl-CoA hydratase/isomerase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,peroxisome
    text present in the peroxisomes of human hepatocytes
    basic FUNCTION
  • delta (3)-cis-delta (2)-trans-enoyl-CoA isomerase
  • isomerizing both 3-cis and 3 transdouble bonds into the 2-transform in a range of enoyl-CoA species
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid, fatty-acid and sterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers with WNT10A
    tumoral     --over  
    in cervical cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS