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FLASH GENE
Symbol PAK6 contributors: mct - updated : 27-10-2016
HGNC name p21(CDKN1A)-activated kinase 6
HGNC id 16061
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal regulatory domain, CDC42/Rac interactive binding domain
  • a GBD (GTPase binding)/CDC42/RAC1 binding domain (CRIB)
  • a C terminal kinase domain with the Ser/Thr kinase signature
    • HOMOLOGY
    intraspecies homolog to PAK4, PAK2
    Homologene
    FAMILY group B family of PAK serine/threonine kinases
    CATEGORY enzyme , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text cotranslocated into the nucleus with AR in response to antigen
    basic FUNCTION
  • repressing specifically AR-mediated transcription
  • downstream effetor of CDC2 and RAC
  • mediator of filopodia formation, playing a role in the reorganisation of the actin cytoskeleton (suggesting a role for the Golgi in cell morphogenesis)
  • plays a role in the cellular response to stress-related signals
  • potent regulator of RAF1 activity and may control RAF1 dependent signaling at mitochondria
  • contributes to prostate carcinoma development and progression after androgen deprivation therapy, and that it may play roles in the regulation of motility and in stress responses
  • PAK6 and PAK7 are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory
  • may potentially play important roles in CNS pathophysiology after traumatic brain injury
  • critical molecule coordinating cytoskeletal systems for efficient cell migration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text cell structure
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • androgen receptor (AR)
  • CDC42 and RAC1
  • activating the JNK pathway
  • antagonizing Rho in the pathway leading to neurite development
  • RHOD inhibits RHOC-ROCK-Dependent cell contraction via PAK6
    • cell & other
    REGULATION
    activated by MAP2K6 (stimulated by constitutively active MAP kinase kinase 6 (MAP2K6), an upstream activator of MAPK14)
    repressed by basal PAK6 kinase activity was repressed by a MAPK14 antagonist
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary and metastatic prostate carcinoma, and was further increased in tumors that relapsed after androgen deprivation therapy (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    PAK7/PAK6 double knockout mice exhibit defects in behavior, memory, and learning