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FLASH GENE

Symbol

PAK6

contributors: mct - updated : 27-10-2016

HGNC name	p21(CDKN1A)-activated kinase 6
HGNC id	16061

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001128628 11 - 3939 - 681 - 2002 12032833 NM_001128629 10 - 3856 - 681 - 2002 12032833 NM_020168 11 - 3961 - 681 - 2002 12032833

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Mus musculus Reproductive male system prostate     moderately Homo sapiens   male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal regulatory domain, CDC42/Rac interactive binding domain
	a GBD (GTPase binding)/CDC42/RAC1 binding domain (CRIB)
	a C terminal kinase domain with the Ser/Thr kinase signature

HOMOLOGY

intraspecies

homolog to PAK4, PAK2

Homologene

FAMILY

group B family of PAK serine/threonine kinases

CATEGORY

enzyme , receptor membrane kinase

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	cotranslocated into the nucleus with AR in response to antigen

basic FUNCTION	repressing specifically AR-mediated transcription
	downstream effetor of CDC2 and RAC
	mediator of filopodia formation, playing a role in the reorganisation of the actin cytoskeleton (suggesting a role for the Golgi in cell morphogenesis)
	plays a role in the cellular response to stress-related signals
	potent regulator of RAF1 activity and may control RAF1 dependent signaling at mitochondria
	contributes to prostate carcinoma development and progression after androgen deprivation therapy, and that it may play roles in the regulation of motility and in stress responses
	PAK6 and PAK7 are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory
	may potentially play important roles in CNS pathophysiology after traumatic brain injury
	critical molecule coordinating cytoskeletal systems for efficient cell migration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	cell structure

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	androgen receptor (AR)
	CDC42 and RAC1
	activating the JNK pathway
	antagonizing Rho in the pathway leading to neurite development
	RHOD inhibits RHOC-ROCK-Dependent cell contraction via PAK6

cell & other

REGULATION

activated by

MAP2K6 (stimulated by constitutively active MAP kinase kinase 6 (MAP2K6), an upstream activator of MAPK14)

repressed by	basal PAK6 kinase activity was repressed by a MAPK14 antagonist

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary and metastatic prostate carcinoma, and was further increased in tumors that relapsed after androgen deprivation therapy (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

PAK7/PAK6 double knockout mice exhibit defects in behavior, memory, and learning