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FLASH GENE
Symbol PAK6 contributors: mct - updated : 27-10-2016
HGNC name p21(CDKN1A)-activated kinase 6
HGNC id 16061
DNA
TYPE functioning gene
STRUCTURE 60.06 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3939 - 681 - 2002 12032833
10 - 3856 - 681 - 2002 12032833
11 - 3961 - 681 - 2002 12032833
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly Mus musculus
Reproductivemale systemprostate  moderately Homo sapiens
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal regulatory domain, CDC42/Rac interactive binding domain
  • a GBD (GTPase binding)/CDC42/RAC1 binding domain (CRIB)
  • a C terminal kinase domain with the Ser/Thr kinase signature
    • HOMOLOGY
    intraspecies homolog to PAK4, PAK2
    Homologene
    FAMILY group B family of PAK serine/threonine kinases
    CATEGORY enzyme , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text cotranslocated into the nucleus with AR in response to antigen
    basic FUNCTION
  • repressing specifically AR-mediated transcription
  • downstream effetor of CDC2 and RAC
  • mediator of filopodia formation, playing a role in the reorganisation of the actin cytoskeleton (suggesting a role for the Golgi in cell morphogenesis)
  • plays a role in the cellular response to stress-related signals
  • potent regulator of RAF1 activity and may control RAF1 dependent signaling at mitochondria
  • contributes to prostate carcinoma development and progression after androgen deprivation therapy, and that it may play roles in the regulation of motility and in stress responses
  • PAK6 and PAK7 are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory
  • may potentially play important roles in CNS pathophysiology after traumatic brain injury
  • critical molecule coordinating cytoskeletal systems for efficient cell migration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text cell structure
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • androgen receptor (AR)
  • CDC42 and RAC1
  • activating the JNK pathway
  • antagonizing Rho in the pathway leading to neurite development
  • RHOD inhibits RHOC-ROCK-Dependent cell contraction via PAK6
    • cell & other
    REGULATION
    activated by MAP2K6 (stimulated by constitutively active MAP kinase kinase 6 (MAP2K6), an upstream activator of MAPK14)
    repressed by basal PAK6 kinase activity was repressed by a MAPK14 antagonist
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary and metastatic prostate carcinoma, and was further increased in tumors that relapsed after androgen deprivation therapy (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    PAK7/PAK6 double knockout mice exhibit defects in behavior, memory, and learning