Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

NKX2-4

contributors: mct - updated : 13-12-2022

HGNC name	NK2 transcription factor related, locus 4 (Drosophila)
HGNC id	7837

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function aberrantly activated NKL homeobox genes NKX2-4 in acute myeloid leukemia (AML), deregulating genes involved in megakaryocytic and erythroid differentiation processes

Susceptibility

to uveal melanoma (UM)

Variant & Polymorphism other	in UM rs452384 is a functional variant that mediates allele-specific binding of the NKX2.4 nuclear factor and the transcriptional activity of the region, including TERT and CLPTM1L

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS