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FLASH GENE
Symbol PCSK7 contributors: - updated : 22-04-2006
HGNC name proprotein convertase subtilisin/kexin type 7
HGNC id 8748
Location 11q23      Physical location : 117.075.788 - 117.102.811
Synonym name
  • lymphoma proprotein convertase
  • prohormone convertase 8, subtilisin-like
  • Synonym symbol(s) LPC, PC7, PC8, SPC7
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text other downstream duplicated and inverted 3' homolog sequence
    STRUCTURE 27.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    text multiple alternatively spliced transcripts
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a preprodomain
  • a subtilisin-like catalytic, serine protease domain Ca2+ dependent
  • an homo B/P domain,
  • a furin cysteine-rich region
  • a transmembrane anchor and a cytoplasmic domain, alternatively spliced (isoforms in various tissues)
  • isoforms Precursor autocatalytically activated
    HOMOLOGY
    Homologene
    FAMILY proprotein convertase subtilisin kexin-like (SPC) subtilase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text trans Golgi network
    basic FUNCTION having ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other HIV-envelope
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    t(11;14) (q23;q32), in high grade lymphoma with the breakpoint between PCSK7 and its inverted counterpart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS