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FLASH GENE
Symbol LAPTM4A contributors: mct - updated : 27-08-2013
HGNC name lysosomal-associated protein transmembrane 4 alpha
HGNC id 6924
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • four predicted transmembrane domains
  • an hydrophilic C-terminus domain encompassed by two putative signal motifs for intracellular localization (Tyr-X-X-hydrophobic AA)
  • a 55 AA C-terminal region that faces the cytoplasm
    • HOMOLOGY
    interspecies homolog to murine Laptm4a
    Homologene
    FAMILY
  • LAPTM4/LAPTM5 transporter family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • intracellular membrane bound compartment (linked by the C terminal domain)
  • membrane protein that requires two tandemly arranged tyrosine-based sorting signals for efficient localization in these compartments
    • basic FUNCTION
  • potential role in the transport of small molecules across endosomal and lysosomal membranes
  • potential role in the transport of nucleoside and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane bound compartment
  • functions to regulate the intracellular compartmentalization of amphipathic solutes and possibly the sensitivity of cells toward anthracyclines, antibiotics, ionophores, nucleobases and organic cations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS